Intermittent High Glucose Elevates Nuclear Localization of EZH2 to Cause H3K27me3-Dependent Repression of KLF2 Leading to Endothelial Inflammation

Epigenetic mechanisms have emerged as one of the key pathways promoting diabetes-associated complications. Herein, we explored the role of enhancer of zeste homolog 2 (EZH2) and its product histone 3 lysine 27 trimethylation (H3K27me3) in high glucose-mediated endothelial inflammation. To examine th...

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Detalles Bibliográficos
Autores principales: Thakar, Sumukh, Katakia, Yash T, Ramakrishnan, Shyam Kumar, Pandya Thakkar, Niyati, Majumder, Syamantak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534226/
https://www.ncbi.nlm.nih.gov/pubmed/34685528
http://dx.doi.org/10.3390/cells10102548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534226/
https://www.ncbi.nlm.nih.gov/pubmed/34685528
http://dx.doi.org/10.3390/cells10102548

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