Frequent Epigenetic Inactivation of DIRAS-1 and DIRAS-2 Contributes to Chemo-Resistance in Gliomas

SIMPLE SUMMARY: We investigated the genes DIRAS-1 and DIRAS-2 in terms of their regulation and functional relevance in brain tumors (gliomas). We found that in a majority of patients the expression of both genes is strongly downregulated on the mRNA level when comparing tumors with healthy brain tis...

Descripción completa

Detalles Bibliográficos
Autores principales: Rothhammer-Hampl, Tanja, Liesenberg, Franziska, Hansen, Natalie, Hoja, Sabine, Delic, Sabit, Reifenberger, Guido, Riemenschneider, Markus J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534260/
https://www.ncbi.nlm.nih.gov/pubmed/34680261
http://dx.doi.org/10.3390/cancers13205113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534260/
https://www.ncbi.nlm.nih.gov/pubmed/34680261
http://dx.doi.org/10.3390/cancers13205113

Ejemplares similares