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Frequent Epigenetic Inactivation of DIRAS-1 and DIRAS-2 Contributes to Chemo-Resistance in Gliomas

SIMPLE SUMMARY: We investigated the genes DIRAS-1 and DIRAS-2 in terms of their regulation and functional relevance in brain tumors (gliomas). We found that in a majority of patients the expression of both genes is strongly downregulated on the mRNA level when comparing tumors with healthy brain tis...

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Detalles Bibliográficos
Autores principales:	Rothhammer-Hampl, Tanja, Liesenberg, Franziska, Hansen, Natalie, Hoja, Sabine, Delic, Sabit, Reifenberger, Guido, Riemenschneider, Markus J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534260/ https://www.ncbi.nlm.nih.gov/pubmed/34680261 http://dx.doi.org/10.3390/cancers13205113

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