Zonula occludens 2 and Cell-Cell Contacts Are Required for Normal Nuclear Shape in Epithelia

MAGUK protein ZO-2 is present at tight junctions (TJs) and nuclei. In MDCK ZO-2 knockdown (KD) cells, nuclei exhibit an irregular shape with lobules and indentations. This condition correlates with an increase in DNA double strand breaks, however cells are not senescent and instead become resistant...

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Detalles Bibliográficos
Autores principales: Hernández-Guzmán, Christian, Gallego-Gutiérrez, Helios, Chávez-Munguía, Bibiana, Martín-Tapia, Dolores, González-Mariscal, Lorenza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534263/
https://www.ncbi.nlm.nih.gov/pubmed/34685547
http://dx.doi.org/10.3390/cells10102568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534263/
https://www.ncbi.nlm.nih.gov/pubmed/34685547
http://dx.doi.org/10.3390/cells10102568

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