Discovery of synthetic lethal and tumor suppressor paralog pairs in the human genome

CRISPR screens have accelerated the discovery of important cancer vulnerabilities. However, single-gene knockout phenotypes can be masked by redundancy among related genes. Paralogs constitute two-thirds of the human protein-coding genome, so existing methods are likely inadequate for assaying a lar...

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Detalles Bibliográficos
Autores principales: Parrish, Phoebe C.R., Thomas, James D., Gabel, Austin M., Kamlapurkar, Shriya, Bradley, Robert K., Berger, Alice H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534300/
https://www.ncbi.nlm.nih.gov/pubmed/34469736
http://dx.doi.org/10.1016/j.celrep.2021.109597

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534300/
https://www.ncbi.nlm.nih.gov/pubmed/34469736
http://dx.doi.org/10.1016/j.celrep.2021.109597

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