PI3Kδ Sustains Keratinocyte Hyperproliferation and Epithelial Inflammation: Implications for a Topically Druggable Target in Psoriasis

The phosphatidylinositol 3-kinase (PI3K)-dependent signaling pathway is aberrantly activated in psoriatic lesions and contributes to disease pathogenesis. Among PI3Ks enzymes, PI3Kα, β, and δ isoforms are known to bind the p85 regulatory subunit and mediate activation of AKT and other downstream eff...

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Detalles Bibliográficos
Autores principales: Mercurio, Laura, Morelli, Martina, Scarponi, Claudia, Scaglione, Giovanni Luca, Pallotta, Sabatino, Albanesi, Cristina, Madonna, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534452/
https://www.ncbi.nlm.nih.gov/pubmed/34685616
http://dx.doi.org/10.3390/cells10102636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534452/
https://www.ncbi.nlm.nih.gov/pubmed/34685616
http://dx.doi.org/10.3390/cells10102636

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