Pancreatic β-Cell O-GlcNAc Transferase Overexpression Increases Susceptibility to Metabolic Stressors in Female Mice

The nutrient-sensor O-GlcNAc transferase (Ogt), the sole enzyme that adds an O-GlcNAc-modification onto proteins, plays a critical role for pancreatic β-cell survival and insulin secretion. We hypothesized that β-cell Ogt overexpression would confer protection from β-cell failure in response to meta...

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Detalles Bibliográficos
Autores principales: Mohan, Ramkumar, Jo, Seokwon, Da Sol Chung, Elina, Oribamise, Eunice, Lockridge, Amber, Abrahante-Lloréns, Juan E., Ruan, Hai-Bin, Yang, Xiao-Yong, Alejandro, Emilyn U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534823/
https://www.ncbi.nlm.nih.gov/pubmed/34685781
http://dx.doi.org/10.3390/cells10102801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534823/
https://www.ncbi.nlm.nih.gov/pubmed/34685781
http://dx.doi.org/10.3390/cells10102801

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