Activation of mTORC1 by Free Fatty Acids Suppresses LAMP2 and Autophagy Function via ER Stress in Alcohol-Related Liver Disease

Alcohol-related liver disease (ALD) is characterized by accumulation of hepatic free fatty acids (FFAs) and liver injury. The present study aimed to investigate if mechanistic target of rapamycin complex 1 (mTORC1) plays a role in FFA-induced organelle dysfunction, thereby contributing to the develo...

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Detalles Bibliográficos
Autores principales: Guo, Wei, Zhong, Wei, Hao, Liuyi, Sun, Xinguo, Zhou, Zhanxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535060/
https://www.ncbi.nlm.nih.gov/pubmed/34685712
http://dx.doi.org/10.3390/cells10102730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535060/
https://www.ncbi.nlm.nih.gov/pubmed/34685712
http://dx.doi.org/10.3390/cells10102730

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