Coactivation of GSK3β and IGF-1 Attenuates Amyotrophic Lateral Sclerosis Nerve Fiber Cytopathies in SOD1 Mutant Patient-Derived Motor Neurons

Amyotrophic lateral sclerosis (ALS) is a progressive nervous system disease that causes motor neuron (MN) degeneration and results in patient death within a few years. To recapitulate the cytopathies of ALS patients’ MNs, SOD1(G85R) mutant and corrected SOD1(G85G) isogenic-induced pluripotent stem c...

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Detalles Bibliográficos
Autores principales: Ting, Hsiao-Chien, Yang, Hui-I, Harn, Horng-Jyh, Chiu, Ing-Ming, Su, Hong-Lin, Li, Xiang, Chen, Mei-Fang, Ho, Tsung-Jung, Liu, Ching-Ann, Tsai, Yung-Jen, Chiou, Tzyy-Wen, Lin, Shinn-Zong, Chang, Chia-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535155/
https://www.ncbi.nlm.nih.gov/pubmed/34685754
http://dx.doi.org/10.3390/cells10102773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535155/
https://www.ncbi.nlm.nih.gov/pubmed/34685754
http://dx.doi.org/10.3390/cells10102773

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