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Coactivation of GSK3β and IGF-1 Attenuates Amyotrophic Lateral Sclerosis Nerve Fiber Cytopathies in SOD1 Mutant Patient-Derived Motor Neurons
Amyotrophic lateral sclerosis (ALS) is a progressive nervous system disease that causes motor neuron (MN) degeneration and results in patient death within a few years. To recapitulate the cytopathies of ALS patients’ MNs, SOD1(G85R) mutant and corrected SOD1(G85G) isogenic-induced pluripotent stem c...
Autores principales: | Ting, Hsiao-Chien, Yang, Hui-I, Harn, Horng-Jyh, Chiu, Ing-Ming, Su, Hong-Lin, Li, Xiang, Chen, Mei-Fang, Ho, Tsung-Jung, Liu, Ching-Ann, Tsai, Yung-Jen, Chiou, Tzyy-Wen, Lin, Shinn-Zong, Chang, Chia-Yu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535155/ https://www.ncbi.nlm.nih.gov/pubmed/34685754 http://dx.doi.org/10.3390/cells10102773 |
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