Comparative Transcriptome Analysis in Monocyte-Derived Macrophages of Asymptomatic GBA Mutation Carriers and Patients with GBA-Associated Parkinson’s Disease

Mutations of the GBA gene, encoding for lysosomal enzyme glucocerebrosidase (GCase), are the greatest genetic risk factor for Parkinson’s disease (PD) with frequency between 5% and 20% across the world. N370S and L444P are the two most common mutations in the GBA gene. PD carriers of severe mutation...

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Detalles Bibliográficos
Autores principales: Usenko, Tatiana, Bezrukova, Anastasia, Basharova, Katerina, Panteleeva, Alexandra, Nikolaev, Mikhail, Kopytova, Alena, Miliukhina, Irina, Emelyanov, Anton, Zakharova, Ekaterina, Pchelina, Sofya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535749/
https://www.ncbi.nlm.nih.gov/pubmed/34680941
http://dx.doi.org/10.3390/genes12101545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535749/
https://www.ncbi.nlm.nih.gov/pubmed/34680941
http://dx.doi.org/10.3390/genes12101545

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