Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B

Toxin B (TcdB) is a primary cause of Clostridioides difficile infection (CDI). This toxin acts by glucosylating small GTPases in the Rho/Ras families, but the structural basis for TcdB recognition and selectivity of specific GTPase substrates remain unsolved. Here, we report the cocrystal structures...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Zheng, Zhang, Sicai, Chen, Peng, Tian, Songhai, Zeng, Ji, Perry, Kay, Dong, Min, Jin, Rongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535798/
https://www.ncbi.nlm.nih.gov/pubmed/34678063
http://dx.doi.org/10.1126/sciadv.abi4582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535798/
https://www.ncbi.nlm.nih.gov/pubmed/34678063
http://dx.doi.org/10.1126/sciadv.abi4582

Ejemplares similares