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Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B

Toxin B (TcdB) is a primary cause of Clostridioides difficile infection (CDI). This toxin acts by glucosylating small GTPases in the Rho/Ras families, but the structural basis for TcdB recognition and selectivity of specific GTPase substrates remain unsolved. Here, we report the cocrystal structures...

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Detalles Bibliográficos
Autores principales:	Liu, Zheng, Zhang, Sicai, Chen, Peng, Tian, Songhai, Zeng, Ji, Perry, Kay, Dong, Min, Jin, Rongsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535798/ https://www.ncbi.nlm.nih.gov/pubmed/34678063 http://dx.doi.org/10.1126/sciadv.abi4582

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