Osteocalcin attenuates oligodendrocyte differentiation and myelination via GPR37 signaling in the mouse brain

The bone-derived hormone osteocalcin (OCN) is crucial for brain development and neural cognitive functions, yet the exact roles of OCN in central nervous system (CNS) remain elusive. Here, we find that genetic deletion of OCN facilitates oligodendrocyte (OL) differentiation and hypermyelination in t...

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Detalles Bibliográficos
Autores principales: Qian, Zhengjiang, Li, Hongchao, Yang, Haiyang, Yang, Qin, Lu, Zhonghua, Wang, Liping, Chen, Ying, Li, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535816/
https://www.ncbi.nlm.nih.gov/pubmed/34678058
http://dx.doi.org/10.1126/sciadv.abi5811

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535816/
https://www.ncbi.nlm.nih.gov/pubmed/34678058
http://dx.doi.org/10.1126/sciadv.abi5811

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