NLRC4 inflammasome–dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice

Inflammasome is an innate immune defense mechanism, but its overactivation can lead to host death. Here, we show that cell death dictates mouse death caused by NLRC4 inflammasome overactivation. To execute NLRC4-dependent cell death, three death pathways complement each other in a specific order: Py...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Peipei, Liu, Yifei, Hu, Lichen, Huang, Kai, Hong, Mao, Wang, Yuze, Fan, Xinrui, Ulevitch, Richard J., Han, Jiahuai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535822/
https://www.ncbi.nlm.nih.gov/pubmed/34678072
http://dx.doi.org/10.1126/sciadv.abi9471

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535822/
https://www.ncbi.nlm.nih.gov/pubmed/34678072
http://dx.doi.org/10.1126/sciadv.abi9471

Ejemplares similares