Cargando…
NLRC4 inflammasome–dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice
Inflammasome is an innate immune defense mechanism, but its overactivation can lead to host death. Here, we show that cell death dictates mouse death caused by NLRC4 inflammasome overactivation. To execute NLRC4-dependent cell death, three death pathways complement each other in a specific order: Py...
Autores principales: | Zhang, Peipei, Liu, Yifei, Hu, Lichen, Huang, Kai, Hong, Mao, Wang, Yuze, Fan, Xinrui, Ulevitch, Richard J., Han, Jiahuai |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535822/ https://www.ncbi.nlm.nih.gov/pubmed/34678072 http://dx.doi.org/10.1126/sciadv.abi9471 |
Ejemplares similares
-
Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells
por: Szymczak, Florian, et al.
Publicado: (2022) -
Protocol for reconstitution of oligomeric assembly of NAIP5-NLRC4 inflammasome in vitro
por: Wu, Xiurong, et al.
Publicado: (2023) -
Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced death
por: Liu, Lin, et al.
Publicado: (2022) -
ANT-dependent MPTP underlies necrotic myofiber death in muscular dystrophy
por: Bround, Michael J., et al.
Publicado: (2023) -
Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy
por: Choi, Insup, et al.
Publicado: (2022)