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The Second Allele: A Key to Understanding the Timing of Sporadic and Hereditary Colorectal Tumorigenesis
Our understanding of the molecular basis of colorectal neoplasia is derived from Mendelian genetics, with tumor suppressor genes contributing more to the deregulation of growth than oncogenes. In patients with hereditary syndromes, expression of one allele of a key tumor suppressor gene is absent at...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536005/ https://www.ncbi.nlm.nih.gov/pubmed/34680910 http://dx.doi.org/10.3390/genes12101515 |