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The Second Allele: A Key to Understanding the Timing of Sporadic and Hereditary Colorectal Tumorigenesis

Our understanding of the molecular basis of colorectal neoplasia is derived from Mendelian genetics, with tumor suppressor genes contributing more to the deregulation of growth than oncogenes. In patients with hereditary syndromes, expression of one allele of a key tumor suppressor gene is absent at...

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Detalles Bibliográficos
Autores principales:	Abbass, Mohammed Ali, Leach, Brandie, Church, James Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536005/ https://www.ncbi.nlm.nih.gov/pubmed/34680910 http://dx.doi.org/10.3390/genes12101515

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