SARS-CoV-2 Spike Protein Disrupts Blood–Brain Barrier Integrity via RhoA Activation

The SARS-CoV-2 spike protein has been shown to disrupt blood–brain barrier (BBB) function, but its pathogenic mechanism of action is unknown. Whether angiotensin converting enzyme 2 (ACE2), the viral binding site for SARS-CoV-2, contributes to the spike protein-induced barrier disruption also remain...

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Detalles Bibliográficos
Autores principales: DeOre, Brandon J., Tran, Kiet A., Andrews, Allison M., Ramirez, Servio H., Galie, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536479/
https://www.ncbi.nlm.nih.gov/pubmed/34687399
http://dx.doi.org/10.1007/s11481-021-10029-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536479/
https://www.ncbi.nlm.nih.gov/pubmed/34687399
http://dx.doi.org/10.1007/s11481-021-10029-0

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