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Gene dosage effects of poly(A) track-engineered hypomorphs

Manipulation of gene activity through creation of hypomorphic mutants has been a long-standing tool in examining gene function. Our previous studies have indicated that hypomorphic mutants could be created by inserting cis-regulatory sequences composed of consecutive adenosine nucleotides called pol...

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Detalles Bibliográficos
Autores principales: Powell, Geralle, Pavlovic Djuranovic, Slavica, Djuranovic, Sergej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536507/
https://www.ncbi.nlm.nih.gov/pubmed/34729253
http://dx.doi.org/10.1016/j.omtn.2021.10.005