Topoisomerase poisoning by the flavonoid nevadensin triggers DNA damage and apoptosis in human colon carcinoma HT29 cells

Nevadensin, an abundant polyphenol of basil, is reported to reduce alkenylbenzene DNA adduct formation. Furthermore, it has a wide spectrum of further pharmacological properties. The presented study focuses the impact of nevadensin on topoisomerases (TOPO) in vitro. Considering the DNA-intercalating...

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Detalles Bibliográficos
Autores principales: Müller, Lena, Schütte, Larissa Rhonda Friederike, Bücksteeg, David, Alfke, Julian, Uebel, Thomas, Esselen, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Genotoxicity and Carcinogenicity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536574/
https://www.ncbi.nlm.nih.gov/pubmed/34635930
http://dx.doi.org/10.1007/s00204-021-03162-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536574/
https://www.ncbi.nlm.nih.gov/pubmed/34635930
http://dx.doi.org/10.1007/s00204-021-03162-5

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