Cumulative DNA damage by repeated low-dose cisplatin injection promotes the transition of acute to chronic kidney injury in mice

Cisplatin is a commonly used anticancer drug, but nephrotoxicity is a dose-limiting adverse effect. Recent experimental and clinical observations have demonstrated that multiple injections of cisplatin induce the transition to chronic kidney disease; however, the underlying mechanisms remain unclear...

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Detalles Bibliográficos
Autores principales: Yamashita, Noriyuki, Nakai, Kunihiro, Nakata, Tomohiro, Nakamura, Itaru, Kirita, Yuhei, Matoba, Satoaki, Humphreys, Benjamin D., Tamagaki, Keiichi, Kusaba, Tetsuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536734/
https://www.ncbi.nlm.nih.gov/pubmed/34686727
http://dx.doi.org/10.1038/s41598-021-00392-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536734/
https://www.ncbi.nlm.nih.gov/pubmed/34686727
http://dx.doi.org/10.1038/s41598-021-00392-6

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