Engineering digitizer circuits for chemical and genetic screens in human cells

Cell-based transcriptional reporters are invaluable in high-throughput compound and CRISPR screens for identifying compounds or genes that can impact a pathway of interest. However, many transcriptional reporters have weak activities and transient responses. This can result in overlooking therapeuti...

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Detalles Bibliográficos
Autores principales: Wong, Nicole M., Frias, Elizabeth, Sigoillot, Frederic D., Letendre, Justin H., Hild, Marc, Wong, Wilson W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536748/
https://www.ncbi.nlm.nih.gov/pubmed/34686672
http://dx.doi.org/10.1038/s41467-021-26359-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536748/
https://www.ncbi.nlm.nih.gov/pubmed/34686672
http://dx.doi.org/10.1038/s41467-021-26359-9

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