Targeting miR-126 in inv(16) acute myeloid leukemia inhibits leukemia development and leukemia stem cell maintenance

Acute myeloid leukemia (AML) harboring inv(16)(p13q22) expresses high levels of miR-126. Here we show that the CBFB-MYH11 (CM) fusion gene upregulates miR-126 expression through aberrant miR-126 transcription and perturbed miR-126 biogenesis via the HDAC8/RAN-XPO5-RCC1 axis. Aberrant miR-126 upregul...

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Detalles Bibliográficos
Autores principales: Zhang, Lianjun, Nguyen, Le Xuan Truong, Chen, Ying-Chieh, Wu, Dijiong, Cook, Guerry J., Hoang, Dinh Hoa, Brewer, Casey J., He, Xin, Dong, Haojie, Li, Shu, Li, Man, Zhao, Dandan, Qi, Jing, Hua, Wei-Kai, Cai, Qi, Carnahan, Emily, Chen, Wei, Wu, Xiwei, Swiderski, Piotr, Rockne, Russell C., Kortylewski, Marcin, Li, Ling, Zhang, Bin, Marcucci, Guido, Kuo, Ya-Huei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536759/
https://www.ncbi.nlm.nih.gov/pubmed/34686664
http://dx.doi.org/10.1038/s41467-021-26420-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536759/
https://www.ncbi.nlm.nih.gov/pubmed/34686664
http://dx.doi.org/10.1038/s41467-021-26420-7

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