Anti-cancer efficacy including Rb-deficient tumors and VHL-independent HIF1α proteasomal destabilization by dual targeting of CDK1 or CDK4/6 and HSP90

A prevalent characteristic of solid tumors is intra-tumoral hypoxia. Hypoxia-inducible factor 1α (HIF1α) predominantly mediates the adaptive response to O(2) oscillation and is linked to multiple malignant hallmarks. Here we describe a strategy to robustly target HIF1α by dual inhibition of CDK(s) a...

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Detalles Bibliográficos
Autores principales: Zhao, Shuai, Zhou, Lanlan, Dicker, David T., Lev, Avital, Zhang, Shengliang, Ross, Eric, El-Deiry, Wafik S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536770/
https://www.ncbi.nlm.nih.gov/pubmed/34686682
http://dx.doi.org/10.1038/s41598-021-00150-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536770/
https://www.ncbi.nlm.nih.gov/pubmed/34686682
http://dx.doi.org/10.1038/s41598-021-00150-8

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