A human multi-lineage hepatic organoid model for liver fibrosis

To investigate the pathogenesis of a congenital form of hepatic fibrosis, human hepatic organoids were engineered to express the most common causative mutation for Autosomal Recessive Polycystic Kidney Disease (ARPKD). Here we show that these hepatic organoids develop the key features of ARPKD liver...

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Detalles Bibliográficos
Autores principales: Guan, Yuan, Enejder, Annika, Wang, Meiyue, Fang, Zhuoqing, Cui, Lu, Chen, Shih-Yu, Wang, Jingxiao, Tan, Yalun, Wu, Manhong, Chen, Xinyu, Johansson, Patrik K., Osman, Issra, Kunimoto, Koshi, Russo, Pierre, Heilshorn, Sarah C., Peltz, Gary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536785/
https://www.ncbi.nlm.nih.gov/pubmed/34686668
http://dx.doi.org/10.1038/s41467-021-26410-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536785/
https://www.ncbi.nlm.nih.gov/pubmed/34686668
http://dx.doi.org/10.1038/s41467-021-26410-9

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