Targeting Tat–TAR RNA Interaction for HIV-1 Inhibition

The HIV-1 Tat protein interacts with TAR RNA and recruits CDK9/cyclin T1 and other host factors to induce HIV-1 transcription. Thus, Tat–TAR RNA interaction, which is unique for HIV-1, represents an attractive target for anti-HIV-1 therapeutics. To target Tat–TAR RNA interaction, we used a crystal s...

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Detalles Bibliográficos
Autores principales: Alanazi, Awadh, Ivanov, Andrey, Kumari, Namita, Lin, Xionghao, Wang, Songping, Kovalskyy, Dmytro, Nekhai, Sergei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536978/
https://www.ncbi.nlm.nih.gov/pubmed/34696435
http://dx.doi.org/10.3390/v13102004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536978/
https://www.ncbi.nlm.nih.gov/pubmed/34696435
http://dx.doi.org/10.3390/v13102004

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