Rutaecarpine, an Alkaloid from Evodia rutaecarpa, Can Prevent Platelet Activation in Humans and Reduce Microvascular Thrombosis in Mice: Crucial Role of the PI3K/Akt/GSK3β  Signal Axis through a Cyclic Nucleotides/VASP—Independent Mechanism

The role of activated platelets in acute and chronic cardiovascular diseases (CVDs) is well established. Therefore, antiplatelet drugs significantly reduce the risk of severe CVDs. Evodia rutaecarpa (Wu-Chu-Yu) is a well-known Chinese medicine, and rutaecarpine (Rut) is a main bioactive component wi...

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Detalles Bibliográficos
Autores principales: Huang, Chun-Jen, Huang, Wei-Chieh, Lin, Wei-Ting, Shu, Lan-Hsin, Sheu, Joen-Rong, Tran, Oanh-Thi, Hsia, Chih-Wei, Jayakumar, Thanasekaran, Bhavan, Periyakali Saravana, Hsieh, Cheng-Ying, Chang, Chao-Chien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537152/
https://www.ncbi.nlm.nih.gov/pubmed/34681769
http://dx.doi.org/10.3390/ijms222011109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537152/
https://www.ncbi.nlm.nih.gov/pubmed/34681769
http://dx.doi.org/10.3390/ijms222011109

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