Hepatocyte-Specific Phgdh-Deficient Mice Culminate in Mild Obesity, Insulin Resistance, and Enhanced Vulnerability to Protein Starvation

l-Serine (Ser) is synthesized de novo from 3-phosphoglycerate via the phosphorylated pathway committed by phosphoglycerate dehydrogenase (Phgdh). A previous study reported that feeding a protein-free diet increased the enzymatic activity of Phgdh in the liver and enhanced Ser synthesis in the rat li...

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Detalles Bibliográficos
Autores principales: Hamano, Momoko, Esaki, Kayoko, Moriyasu, Kazuki, Yasuda, Tokio, Mohri, Sinya, Tashiro, Kosuke, Hirabayashi, Yoshio, Furuya, Shigeki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537398/
https://www.ncbi.nlm.nih.gov/pubmed/34684470
http://dx.doi.org/10.3390/nu13103468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537398/
https://www.ncbi.nlm.nih.gov/pubmed/34684470
http://dx.doi.org/10.3390/nu13103468

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