Model-Informed Precision Dosing during Infliximab Induction Therapy Reduces Variability in Exposure and Endoscopic Improvement between Patients with Ulcerative Colitis

Model-informed precision dosing (MIPD) may be a solution to therapeutic failure of infliximab for patients with ulcerative colitis (UC), as underexposure could be avoided, and the probability of endoscopic improvement (pEI; Mayo endoscopic subscore ≤ 1) could be optimized. To investigate in silico w...

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Detalles Bibliográficos
Autores principales: Faelens, Ruben, Wang, Zhigang, Bouillon, Thomas, Declerck, Paul, Ferrante, Marc, Vermeire, Séverine, Dreesen, Erwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537637/
https://www.ncbi.nlm.nih.gov/pubmed/34683916
http://dx.doi.org/10.3390/pharmaceutics13101623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537637/
https://www.ncbi.nlm.nih.gov/pubmed/34683916
http://dx.doi.org/10.3390/pharmaceutics13101623

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