Folium Sennae Increased the Bioavailability of Methotrexate through Modulation on MRP 2 and BCRP

Folium Sennae (FS), a popular laxative (Senna), contains polyphenolic anthranoids, whose conjugation metabolites are probable modulators of multidrug resistance-associated proteins (MRPs) and breast cancer resistance protein (BCRP). We suspected that the combined use of FS might alter the pharmacoki...

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Detalles Bibliográficos
Autores principales: Yu, Chung-Ping, Peng, Yu-Hsuan, Huang, Ching-Ya, Hsieh, Yow-Wen, Hou, Yu-Chi, Lin, Shiuan-Pey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537691/
https://www.ncbi.nlm.nih.gov/pubmed/34681260
http://dx.doi.org/10.3390/ph14101036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537691/
https://www.ncbi.nlm.nih.gov/pubmed/34681260
http://dx.doi.org/10.3390/ph14101036

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