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Folium Sennae Increased the Bioavailability of Methotrexate through Modulation on MRP 2 and BCRP

Folium Sennae (FS), a popular laxative (Senna), contains polyphenolic anthranoids, whose conjugation metabolites are probable modulators of multidrug resistance-associated proteins (MRPs) and breast cancer resistance protein (BCRP). We suspected that the combined use of FS might alter the pharmacoki...

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Detalles Bibliográficos
Autores principales:	Yu, Chung-Ping, Peng, Yu-Hsuan, Huang, Ching-Ya, Hsieh, Yow-Wen, Hou, Yu-Chi, Lin, Shiuan-Pey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537691/ https://www.ncbi.nlm.nih.gov/pubmed/34681260 http://dx.doi.org/10.3390/ph14101036

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