Sub-Cellular Metabolomics Contributes Mitochondria-Specific Metabolic Insights to a Mouse Model of Leigh Syndrome

Direct injury of mitochondrial respiratory chain (RC) complex I by Ndufs4 subunit mutations results in complex I deficiency (CID) and a progressive encephalomyopathy, known as Leigh syndrome. While mitochondrial, cytosolic and multi-organelle pathways are known to be involved in the neuromuscular LS...

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Detalles Bibliográficos
Autores principales: van der Walt, Gunter, Lindeque, Jeremie Z., Mason, Shayne, Louw, Roan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537744/
https://www.ncbi.nlm.nih.gov/pubmed/34677373
http://dx.doi.org/10.3390/metabo11100658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537744/
https://www.ncbi.nlm.nih.gov/pubmed/34677373
http://dx.doi.org/10.3390/metabo11100658

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