Synthesis and Biological Evaluation of (S)-2-(Substituted arylmethyl)-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-3-carboxamide Analogs and Their Synergistic Effect against PTEN-Deficient MDA-MB-468 Cells

A series of twenty-six compounds of furfuryl or benzyl tetrahydropyrazino[1,2-a]indole analogs were synthesized and evaluated for cytotoxic activity against the estrogen receptor (ER)-positive breast cancer cell line (MCF-7) and the epidermal growth factor receptor (EGFR) over-expressed triple-negat...

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Detalles Bibliográficos
Autores principales: Kwon, Ye-Mi, Kim, Sou Hyun, Jung, Young-Suk, Kwak, Jae-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537755/
https://www.ncbi.nlm.nih.gov/pubmed/34681198
http://dx.doi.org/10.3390/ph14100974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537755/
https://www.ncbi.nlm.nih.gov/pubmed/34681198
http://dx.doi.org/10.3390/ph14100974

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