Pioglitazone Is a Mild Carrier-Dependent Uncoupler of Oxidative Phosphorylation and a Modulator of Mitochondrial Permeability Transition

Pioglitazone (PIO) is an insulin-sensitizing antidiabetic drug, which normalizes glucose and lipid metabolism but may provoke heart and liver failure and chronic kidney diseases. Both therapeutic and adverse effects of PIO can be accomplished through mitochondrial targets. Here, we explored the capa...

Descripción completa

Detalles Bibliográficos
Autores principales: Kharechkina, Ekaterina S., Nikiforova, Anna B., Belosludtsev, Konstantin N., Rokitskaya, Tatyana I., Antonenko, Yuri N., Kruglov, Alexey G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537895/
https://www.ncbi.nlm.nih.gov/pubmed/34681269
http://dx.doi.org/10.3390/ph14101045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537895/
https://www.ncbi.nlm.nih.gov/pubmed/34681269
http://dx.doi.org/10.3390/ph14101045

Ejemplares similares