Macrophage-Dependent Interleukin-6-Production and Inhibition of I(K) Contributes to Acquired QT Prolongation in Lipotoxic Guinea Pig Heart

In the heart, the delayed rectifier K current, I(K), composed of the rapid (I(Kr)) and slow (I(Ks)) components contributes prominently to normal cardiac repolarization. In lipotoxicity, chronic elevation of pro-inflammatory cytokines may remodel I(K), elevating the risk for ventricular arrythmias an...

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Detalles Bibliográficos
Autores principales: Chowdhury, Md. Kamrul Hasan, Martinez-Mateu, Laura, Do, Jenny, Aromolaran, Kelly A., Saiz, Javier, Aromolaran, Ademuyiwa S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537919/
https://www.ncbi.nlm.nih.gov/pubmed/34681909
http://dx.doi.org/10.3390/ijms222011249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537919/
https://www.ncbi.nlm.nih.gov/pubmed/34681909
http://dx.doi.org/10.3390/ijms222011249

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