Synthesis and Biological Evaluation of New Bis-Indolinone Derivatives Endowed with Cytotoxic Activity

A series of new Knoevenagel adducts, bearing two indolinone systems, has been synthesized and evaluated on 60 human cancer cell lines according to protocols available at the National Cancer Institute (Bethesda, MD, USA). Some derivatives proved to be potent antiproliferative agents, showing GI(50) v...

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Detalles Bibliográficos
Autores principales: Morigi, Rita, Catanzaro, Elena, Locatelli, Alessandra, Calcabrini, Cinzia, Pellicioni, Valentina, Leoni, Alberto, Fimognari, Carmela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537952/
https://www.ncbi.nlm.nih.gov/pubmed/34684858
http://dx.doi.org/10.3390/molecules26206277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537952/
https://www.ncbi.nlm.nih.gov/pubmed/34684858
http://dx.doi.org/10.3390/molecules26206277

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