Direct Delivery of ANA-TA9, a Peptide Capable of Aβ Hydrolysis, to the Brain by Intranasal Administration

We have recently reported Catalytides (Catalytic peptides) JAL-TA9 (YKGSGFRMI) and ANA-TA9 (SKGQAYRMI), which are the first Catalytides found to cleave Aβ42. Although the Catalytides must be delivered to the brain parenchyma to treat Alzheimer’s disease, the blood–brain barrier (BBB) limits their en...

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Detalles Bibliográficos
Autores principales: Hatakawa, Yusuke, Tanaka, Akiko, Furubayashi, Tomoyuki, Nakamura, Rina, Konishi, Motomi, Akizawa, Toshifumi, Sakane, Toshiyasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538057/
https://www.ncbi.nlm.nih.gov/pubmed/34683967
http://dx.doi.org/10.3390/pharmaceutics13101673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538057/
https://www.ncbi.nlm.nih.gov/pubmed/34683967
http://dx.doi.org/10.3390/pharmaceutics13101673

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