Passage Number-Induced Replicative Senescence Modulates the Endothelial Cell Response to Protein-Bound Uremic Toxins

Endothelial aging may be induced early in pathological situations. The uremic toxins indoxyl sulfate (IS) and p-cresol (PC) accumulate in the plasma of chronic kidney disease (CKD) patients, causing accelerated endothelial aging, increased cardiovascular events and mortality. However, the mechanisms...

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Detalles Bibliográficos
Autores principales: Guerrero, Fatima, Carmona, Andres, Jimenez, Maria Jose, Obrero, Teresa, Pulido, Victoria, Moreno, Juan Antonio, Soriano, Sagrario, Martín-Malo, Alejandro, Aljama, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538293/
https://www.ncbi.nlm.nih.gov/pubmed/34679030
http://dx.doi.org/10.3390/toxins13100738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538293/
https://www.ncbi.nlm.nih.gov/pubmed/34679030
http://dx.doi.org/10.3390/toxins13100738

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