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Passage Number-Induced Replicative Senescence Modulates the Endothelial Cell Response to Protein-Bound Uremic Toxins

Endothelial aging may be induced early in pathological situations. The uremic toxins indoxyl sulfate (IS) and p-cresol (PC) accumulate in the plasma of chronic kidney disease (CKD) patients, causing accelerated endothelial aging, increased cardiovascular events and mortality. However, the mechanisms...

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Detalles Bibliográficos
Autores principales:	Guerrero, Fatima, Carmona, Andres, Jimenez, Maria Jose, Obrero, Teresa, Pulido, Victoria, Moreno, Juan Antonio, Soriano, Sagrario, Martín-Malo, Alejandro, Aljama, Pedro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538293/ https://www.ncbi.nlm.nih.gov/pubmed/34679030 http://dx.doi.org/10.3390/toxins13100738

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