Macrophage Depletion via Clodronate Pretreatment Reduces Transgene Expression from AAV Vectors In Vivo

Adeno-associated virus is a popular gene delivery vehicle for gene therapy studies. A potential roadblock to widespread clinical adoption is the high vector doses required for efficient transduction in vivo, and the potential for subsequent immune responses that may limit prolonged transgene express...

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Detalles Bibliográficos
Autores principales: Yu, Darrick L., Chow, Natalie S. M., Bridle, Byram W., Wootton, Sarah K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538323/
https://www.ncbi.nlm.nih.gov/pubmed/34696433
http://dx.doi.org/10.3390/v13102002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538323/
https://www.ncbi.nlm.nih.gov/pubmed/34696433
http://dx.doi.org/10.3390/v13102002

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