Troglitazone-Induced PRODH/POX-Dependent Apoptosis Occurs in the Absence of Estradiol or ERβ in ER-Negative Breast Cancer Cells

SIMPLE SUMMARY: PRODH/POX (proline dehydrogenase/proline oxidase) is a mitochondrial enzyme that catalyzes proline degradation generating reactive oxygen species (ROS). Estrogens limit proline availability for PRODH/POX by stimulating collagen biosynthesis. It has been considered that estrogens dete...

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Detalles Bibliográficos
Autores principales: Lewoniewska, Sylwia, Oscilowska, Ilona, Huynh, Thi Yen Ly, Prokop, Izabela, Baszanowska, Weronika, Bielawska, Katarzyna, Palka, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538344/
https://www.ncbi.nlm.nih.gov/pubmed/34682765
http://dx.doi.org/10.3390/jcm10204641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538344/
https://www.ncbi.nlm.nih.gov/pubmed/34682765
http://dx.doi.org/10.3390/jcm10204641

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