Molecular Properties of Drugs Handled by Kidney OATs and Liver OATPs Revealed by Chemoinformatics and Machine Learning: Implications for Kidney and Liver Disease

In patients with liver or kidney disease, it is especially important to consider the routes of metabolism and elimination of small-molecule pharmaceuticals. Once in the blood, numerous drugs are taken up by the liver for metabolism and/or biliary elimination, or by the kidney for renal elimination....

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Detalles Bibliográficos
Autores principales: Nigam, Anisha K., Ojha, Anupam A., Li, Julia G., Shi, Da, Bhatnagar, Vibha, Nigam, Kabir B., Abagyan, Ruben, Nigam, Sanjay K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538396/
https://www.ncbi.nlm.nih.gov/pubmed/34684013
http://dx.doi.org/10.3390/pharmaceutics13101720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538396/
https://www.ncbi.nlm.nih.gov/pubmed/34684013
http://dx.doi.org/10.3390/pharmaceutics13101720

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