Cargando…

Atorvastatin Ester Regulates Lipid Metabolism in Hyperlipidemia Rats via the PPAR-signaling Pathway and HMGCR Expression in the Liver

Atorvastatin ester (Ate) is a structural trim of atorvastatin that can regulate hyperlipidemia. The purpose of this study was to evaluate the lipid-lowering effect of Ate. Male Sprague Dawley (SD) rats were fed a high-fat diet for seven months and used as a hyperlipidemia model. The lipid level and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Nan, Chen, Chunyun, Wang, Jinhui, Huang, Jian, Yao, Dahong, Li, Chunli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538474/ https://www.ncbi.nlm.nih.gov/pubmed/34681767 http://dx.doi.org/10.3390/ijms222011107

Ejemplares similares

Regulation effect of Aspirin Eugenol Ester on blood lipids in Wistar rats with hyperlipidemia
por: Karam, Isam, et al.
Publicado: (2015)

Synergistic effects of colchicine combined with atorvastatin in rats with hyperlipidemia
por: Huang, Congwu, et al.
Publicado: (2014)

Rewiring Lipid Metabolism by Targeting PCSK9 and HMGCR to Treat Liver Cancer
por: Alannan, Malak, et al.
Publicado: (2022)

Metabonomics Study of the Therapeutic Mechanism of Gynostemma pentaphyllum and Atorvastatin for Hyperlipidemia in Rats
por: Wang, Miao, et al.
Publicado: (2013)

Effectiveness of Coelatura aegyptiaca Extract Combination with Atorvastatin on Experimentally Induced Hyperlipidemia in Rats
por: Mohamed, Ayman Saber, et al.
Publicado: (2019)

The effect of adropin on lipid and glucose metabolism in rats with hyperlipidemia
por: Akcılar, Raziye, et al.
Publicado: (2016)

Cholesteryl Ester Transfer Protein Gene and Effectiveness of Lipid Lowering of Atorvastatin
por: Kolovou, Genovefa, et al.
Publicado: (2010)

Amino Acid Conjugates of 2-Mercaptobenzimidazole Ameliorates High-Fat Diet-Induced Hyperlipidemia in Rats via Attenuation of HMGCR, APOB, and PCSK9
por: Shabbir, Ramla, et al.
Publicado: (2022)

A comparative effect of atorvastatin with other statins in patients of hyperlipidemia
por: Jose, M. Alvin, et al.
Publicado: (2012)

Atorvastatin reduces serum HMGB1 levels in patients with hyperlipidemia
por: JIN, DAOQUN, et al.
Publicado: (2012)

Comparison of Dietary Control and Atorvastatin on High Fat Diet Induced Hepatic Steatosis and Hyperlipidemia in Rats
por: Ji, Guiyuan, et al.
Publicado: (2011)

Anti-HMGCR Myopathy
por: Mohassel, Payam, et al.
Publicado: (2018)

Concomitant attenuation of HMGCR expression and activity enhances the growth inhibitory effect of atorvastatin on TGF-β-treated epithelial cancer cells
por: Warita, Katsuhiko, et al.
Publicado: (2021)

Omega-3 Fatty Acid Based Nanolipid Formulation of Atorvastatin for Treating Hyperlipidemia
por: Sreedhar, Revathy, et al.
Publicado: (2019)

Electroacupuncture regulates hepatic cholesterol synthesis by HMGCR deubiquitination in rats
por: Jin, Shu-wen, et al.
Publicado: (2023)

Effect of lipid lowering tablet on blood lipid in hyperlipidemia model rats
por: Kong, Xuejun, et al.
Publicado: (2018)

PPAR-Alpha Agonist Fenofibrate Combined with Octreotide Acetate in the Treatment of Acute Hyperlipidemia Pancreatitis
por: Bao, Wen, et al.
Publicado: (2021)

Multiparticulate Systems of Ezetimibe Micellar System and Atorvastatin Solid Dispersion Efficacy of Low-Dose Ezetimibe/Atorvastatin on High-Fat Diet-Induced Hyperlipidemia and Hepatic Steatosis in Diabetic Rats
por: Torrado-Salmerón, Carlos, et al.
Publicado: (2021)

Therapeutic targets of hypercholesterolemia: HMGCR and LDLR
por: Ma, Shizhan, et al.
Publicado: (2019)

Anti-HMGCR antibodies in systemic sclerosis
por: Hudson, Marie, et al.
Publicado: (2016)

A comparative study of efficacy of atorvastatin alone and its combination with fenofibrate on lipid profile in type 2 diabetes mellitus patients with hyperlipidemia
por: Lella, Meenakshi, et al.
Publicado: (2013)

Effects of the duration of hyperlipidemia on cerebral lipids, vessels and neurons in rats
por: Yang, Weichun, et al.
Publicado: (2017)

Relationship between genetic polymorphism of drug transporters and the efficacy of Rosuvastatin, atorvastatin and simvastatin in patients with hyperlipidemia
por: Sivkov, Andrey, et al.
Publicado: (2021)

Late-Stage Copper-Catalyzed Radiofluorination of an Arylboronic Ester Derivative of Atorvastatin
por: S. Clemente, Gonçalo, et al.
Publicado: (2019)

Phthalate ester metabolism in the isolated, perfused rat liver system.
por: Jaeger, R J, et al.
Publicado: (1973)

AICAR-Induced Activation of AMPK Inhibits TSH/SREBP-2/HMGCR Pathway in Liver
por: Liu, Shudong, et al.
Publicado: (2015)

The Statin Target Hmgcr Regulates Energy Metabolism and Food Intake through Central Mechanisms
por: Williams, Michael J., et al.
Publicado: (2022)

Atorvastatin Inhibits High-Fat Diet-Induced Lipid Metabolism Disorders in Rats by Inhibiting Bacteroides Reduction and Improving Metabolism
por: Li, Huimin, et al.
Publicado: (2022)

Atorvastatin Restores PPARα Inhibition of Lipid Metabolism Disorders by Downregulating miR-21 Expression to Improve Mitochondrial Function and Alleviate Diabetic Nephropathy Progression
por: Xiang, Jiayi, et al.
Publicado: (2022)

Aspirin eugenol ester regulates cecal contents metabolomic profile and microbiota in an animal model of hyperlipidemia
por: Ma, Ning, et al.
Publicado: (2018)

Influence of atorvastatin on metabolic pattern of rats with pulmonary hypertension
por: Luo, Li, et al.
Publicado: (2021)

Effect of Walnut Meal Peptides on Hyperlipidemia and Hepatic Lipid Metabolism in Rats Fed a High-Fat Diet
por: Yang, Xiao-Yue, et al.
Publicado: (2021)

Comparative Study of Ezetimibe and Atorvastatin Alone and in Combination on Lipid Profile in Rats
por: Prasad, Anju, et al.
Publicado: (2013)

Association between the Lipid Levels and Single Nucleotide Polymorphisms of ABCA1, APOE and HMGCR Genes in Subjects with Spontaneous Preterm Delivery
por: Li, Lin, et al.
Publicado: (2015)

Myopathy with anti-HMGCR antibodies: Perimysium and myofiber pathology
por: Alshehri, Ali, et al.
Publicado: (2015)

Anti-HMGCR Specificity of HALIP: A Confirmatory Study
por: Baucells, Andrés, et al.
Publicado: (2020)

Effect of Concomitant Icosapent Ethyl (Eicosapentaenoic Acid Ethyl Ester) on the Pharmacokinetics of Atorvastatin
por: Braeckman, Rene A., et al.
Publicado: (2014)

Palmiwon attenuates hepatic lipid accumulation and hyperlipidemia in a menopausal rat model
por: Go, Hiroe, et al.
Publicado: (2015)

Atorvastatin associated with gamma glutamyl transpeptidase elevation in a hyperlipidemia patient: A case report and literature review
por: Xu, Yan, et al.
Publicado: (2020)

Untargeted lipidomics and metagenomics reveal the mechanism of aspirin eugenol ester relieving hyperlipidemia in ApoE−/− mice
por: Lu, Xiao-Rong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_76j0sdpu3i633k4furesdeug1t