Drug Penetration into the Central Nervous System: Pharmacokinetic Concepts and In Vitro Model Systems

Delivery of most drugs into the central nervous system (CNS) is restricted by the blood–brain barrier (BBB), which remains a significant bottleneck for development of novel CNS-targeted therapeutics or molecular tracers for neuroimaging. Consistent failure to reliably predict drug efficiency based o...

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Detalles Bibliográficos
Autores principales: Neumaier, Felix, Zlatopolskiy, Boris D., Neumaier, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538549/
https://www.ncbi.nlm.nih.gov/pubmed/34683835
http://dx.doi.org/10.3390/pharmaceutics13101542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538549/
https://www.ncbi.nlm.nih.gov/pubmed/34683835
http://dx.doi.org/10.3390/pharmaceutics13101542

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