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Drug Penetration into the Central Nervous System: Pharmacokinetic Concepts and In Vitro Model Systems

Delivery of most drugs into the central nervous system (CNS) is restricted by the blood–brain barrier (BBB), which remains a significant bottleneck for development of novel CNS-targeted therapeutics or molecular tracers for neuroimaging. Consistent failure to reliably predict drug efficiency based o...

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Detalles Bibliográficos
Autores principales:	Neumaier, Felix, Zlatopolskiy, Boris D., Neumaier, Bernd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538549/ https://www.ncbi.nlm.nih.gov/pubmed/34683835 http://dx.doi.org/10.3390/pharmaceutics13101542

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