Tumor-Associated Microglia/Macrophages as a Predictor for Survival in Glioblastoma and Temozolomide-Induced Changes in CXCR2 Signaling with New Resistance Overcoming Strategy by Combination Therapy

Tumor recurrence is the main challenge in glioblastoma (GBM) treatment. Gold standard therapy temozolomide (TMZ) is known to induce upregulation of IL8/CXCL2/CXCR2 signaling that promotes tumor progression and angiogenesis. Our aim was to verify the alterations on this signaling pathway in human GBM...

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Detalles Bibliográficos
Autores principales: Urbantat, Ruth M., Jelgersma, Claudius, Brandenburg, Susan, Nieminen-Kelhä, Melina, Kremenetskaia, Irina, Zollfrank, Julia, Mueller, Susanne, Rubarth, Kerstin, Koch, Arend, Vajkoczy, Peter, Acker, Gueliz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538679/
https://www.ncbi.nlm.nih.gov/pubmed/34681839
http://dx.doi.org/10.3390/ijms222011180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538679/
https://www.ncbi.nlm.nih.gov/pubmed/34681839
http://dx.doi.org/10.3390/ijms222011180

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