Novel NFκB Inhibitor SC75741 Mitigates Chondrocyte Degradation and Prevents Activated Fibroblast Transformation by Modulating miR-21/GDF-5/SOX5 Signaling

Osteoarthritis (OA) is a common articular disease manifested by the destruction of cartilage and compromised chondrogenesis in the aging population, with chronic inflammation of synovium, which drives OA progression. Importantly, the activated synovial fibroblast (AF) within the synovium facilitates...

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Detalles Bibliográficos
Autores principales: Weng, Pei-Wei, Yadav, Vijesh Kumar, Pikatan, Narpati Wesa, Fong, Iat-Hang, Lin, I-Hsin, Yeh, Chi-Tai, Lee, Wei-Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538686/
https://www.ncbi.nlm.nih.gov/pubmed/34681754
http://dx.doi.org/10.3390/ijms222011082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538686/
https://www.ncbi.nlm.nih.gov/pubmed/34681754
http://dx.doi.org/10.3390/ijms222011082

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