Transcriptome Analysis of Cells Exposed to Actinomycin D and Nutlin-3a Reveals New Candidate p53-Target Genes and Indicates That CHIR-98014 Is an Important Inhibitor of p53 Activity

Co-treatment with actinomycin D and nutlin-3a (A + N) strongly activates p53. Previously we reported that CHIR-98014 (GSK-3 kinase inhibitor), acting in cells exposed to A + N, prevents activation of TREM2-an innate immunity and p53-regulated gene associated with Alzheimer’s disease. In order to fin...

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Detalles Bibliográficos
Autores principales: Łasut-Szyszka, Barbara, Małachowska, Beata, Gdowicz-Kłosok, Agnieszka, Krześniak, Małgorzata, Głowala-Kosińska, Magdalena, Zajkowicz, Artur, Rusin, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538697/
https://www.ncbi.nlm.nih.gov/pubmed/34681730
http://dx.doi.org/10.3390/ijms222011072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538697/
https://www.ncbi.nlm.nih.gov/pubmed/34681730
http://dx.doi.org/10.3390/ijms222011072

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