A Novel Method for Predicting the Human Inherent Clearance and Its Application in the Study of the Pharmacokinetics and Drug–Drug Interaction between Azidothymidine and Fluconazole Mediated by UGT Enzyme

In order to improve the benefit–risk ratio of pharmacokinetic (PK) research in the early development of new drugs, in silico and in vitro methods were constructed and improved. Models of intrinsic clearance rate (CL(int)) were constructed based on the quantitative structure–activity relationship (QS...

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Detalles Bibliográficos
Autores principales: Yuan, Yawen, Zhang, Jun, Fang, Boyu, Xiang, Xiaoqiang, Ma, Guo, Zhang, Shunguo, Zhu, Bin, Cai, Weimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538957/
https://www.ncbi.nlm.nih.gov/pubmed/34684027
http://dx.doi.org/10.3390/pharmaceutics13101734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538957/
https://www.ncbi.nlm.nih.gov/pubmed/34684027
http://dx.doi.org/10.3390/pharmaceutics13101734

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